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Nitrogenous bases covalently linked to a sugar with and without phosphate groups; used for synthesis, cell signaling, and as cofactors in enzymatic reactions; includes pyrimidine, purine, pyridine, flavin, pyrrolopyrimidine, and triazole varieties.
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Guanosine 5'-triphosphate trisodium salt hydrate is an activator of the signal transducing G proteins. It also serves as an energy-rich precursor of mononucleotide units in the enzymatic biosynthesis of DNA and RNA. The chemical formula is C10H13N5Na3O14P3·xH2O and it appears as a white to off-white solid.
Activator of signal transducing G proteins
Energy-rich precursor of mononucleotide units
Involved in enzymatic biosynthesis of DNA and RNA
Appears as a white to off-white solid
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Nicotinamide (CAS 98-92-0) is a small-molecule inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1) an enzyme critical in DNA repair pathways Under pathological conditions such as ischemia or trauma PARP-1 hyperactivation depletes cellular NAD triggering neuronal cell death In vitro studies indicate that transporter-mediated uptake of nicotinamide confers protection against PARP-1-induced astrocyte injury In vivo studies in diabetic rat models demonstrate that nicotinamide administration normalizes hepatic antioxidant enzymes reducing oxidative stress Clinical trials have shown dose-dependent upregulation of frataxin expression following sustained nicotinamide treatment suggesting therapeutic potential in disorders like Friedreich s ataxia
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Tenofovir diphosphate disodium is an antiretroviral agent that inhibits HIV reverse transcriptase DNA (Ki = 1.55 μM) and RNA (Ki = 0.022 μM). This compound is used in AIDS research and appears as a white to off-white solid with a molecular formula of C9H14N5Na2O10P3. In vitro studies have shown minimal inhibitory effects on eukaryotic DNA replication.
Antiretroviral agent
Inhibits HIV reverse transcriptase DNA (Ki = 1.55 μM)
Inhibits HIV reverse transcriptase RNA (Ki = 0.022 μM)
Used in AIDS research
Exhibits minimal inhibitory effects on eukaryotic DNA replication in vitro
White to off-white solid
Molecular formula: C9H14N5Na2O10P3
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L-Guanosine is the L-configuration of Guanosine, a purine nucleoside. It demonstrates anti-herpesvirus activity and can be used in the preparation of supramolecular hydrogel. This product is a solid, ranging from white to off-white in color, and is intended for research use only.
Purine nucleoside
Exhibits anti-herpesvirus activity
Can be used to prepare supramolecular hydrogel
Solid appearance, white to off-white color
Store solid at 4°C, protected from light
Store in solvent at -80°C for 6 months or -20°C for 1 month, protected from light
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Guanosine is an aromatic organic molecule and a purine nucleoside. It is present in the cerebrospinal fluid intestinal cells blood-brain barrier and in brain microvessels.
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